Medication effects on tissue are classified as
desirable and undesirable. A desirable effect occurs when the medication
improves the patient’s health. An undesirable effect occurs when the medication
interferes with the patient’s normal physiology. A medication can have both a
desirable and an undesirable effect. The healthcare provider determines whether
the desirable effects outweigh the undesirable effects before administering the
medication to the patient. Additional medication may be given to reduce the
undesirable effects of another medication. A desirable effect is called the
medication’s therapeutic effect and is the reason for the healthcare provider
to administer the medication. An undesirable effect is called either a side
effect or an adverse side effect, depending on the consequence the undesirable
effect has on the patient. A side effect is an undesirable effect that is
relatively not harmful to the patient, such as drowsiness caused by an
antihistamine. An adverse side effect is an undesirable consequence that is
harmful to the patient, such as when healthy cells are destroyed along with
cancerous cells during chemotherapy.
The Placebo Effect
It is
any treatment (including drugs, psychotherapy, quack therapy, and surgery) that
achieves an ameliorative effect on a symptom or disease but that is in fact
ineffective or is not specifically effective for the condition being treated.
Many effective antianxiety drugs have been prescribed both knowingly and
unknowingly at placebo dosages. Hundreds of studies have demonstrated the
effectiveness of antidepressant drugs for the treatment of depression in a
range of 45 to 80 percent—pretty impressive, but the placebo effectiveness in
depression is also high, ranging from 30 to 50 percent. Placebos are effective
for a variety of conditions. Patients with angina pectoris (insufficient blood
flow to the heart) responded to placebo surgery in which surgeons made only an
incision in the chest. And in a study of the drug propranolol that is used
after heart attacks to prevent further damage, investigators noticed that
patients who took placebo pills regularly had a lower death rate than patients
who took placebos sporadically. Therefore, the placebo effect is not unique to
psychiatric illness. Conversely, what types of patients are not really amenable
to a placebo effect? If you are a type I (insulin-dependent) diabetic, who goes
into hypoglycemic shock, a placebo effect will not help. No matter how much
patient believe in whatever he is or is
not taking, nothing will change the physiological dynamics between circulating
blood glucose level and brain’s extremely high need for this energy substrate.
Medication Safety
The Food and Drug Administration requires
that medication undergo rigorous testing before approving the medication. Testing
includes the following animal studies to determine the medication’s therapeutic
index. A therapeutic index is a ratio between the median lethal dose and the
median effective dose and indicates the safe dose to administer to the patient
to achieve the therapeutic effect. These tests also provide scientists with
information on how the medication is absorbed, distributed, metabolized, and
excreted.
Acute
Toxicity Study: Toxic
effect usually appears within 24 hours with single or multiple exposures. This
is the initial test that determines the dose that is lethal to 50% of tested
laboratory animals.
Sub Acute
Toxicity Study: When
animal species are administered daily doses of the medication for 30 days,
toxic effect appears within 30 days.
Sub
Chronic Toxicity Study: Two animal
species are administered daily doses of the medication for 90 days. Animal test
subjects are given physical examinations and laboratory tests during the 90
days to determine the medication’s effect on organs.
Chronic
Toxicity Study: Two
animal species are administered three dose levels, nontoxic, therapeutic, and
toxic. The medication is usually administered over the life span of the test
animal or the duration that the medication is intended to be given to humans.
Animals are given physical exams and laboratory tests to determine the effect
of the medication on organs and its potential carcinogenicity.
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