Showing posts with label injection. Show all posts
Showing posts with label injection. Show all posts

Saturday, 17 August 2013

DRUG DOSAGE FORMS; Capsules, Tablets and Injections

CAPSULES
In the manufacturing of pharmaceuticals, encapsulation refers to a range of techniques used to enclose medicines in a relatively stable shell known as a capsule, allowing them to be taken orally. Capsules are solid dosage form containing one or more medicinal substances enclosed with in a small shell or container prepared from suitable form of gelatin. They are of two types
Hard gelatin capsules: The basic empty capsule shells are made up of the mixture of the gelatin, sugar and water. They are physically hard. The capsules are made in two parts by dipping metal pins in the gelling agent solution. Before use, the two halves are separated, the capsule is filled with powder or more normally pellets made by the process of Extrusion & Spheronization (either by placing a compressed slug of powder into one half of the capsule, or by filling one half of the capsule with loose powder) and the other half of the capsule is pressed on. With the compressed slug method, weight varies less between capsules.
Soft gelatin capsules: These are prepared from shells of gelatin to which glycerin or polyhydric alcohols such as sorbitol are added to render the gelatin elastic or plastic like. Soft gelatin capsule can be an effective delivery system for oral drugs, especially poorly soluble drugs. This is because the fill can contain liquid ingredients that help increase solubility or permeability of the drug across the membranes in the body. Liquid ingredients are difficult to include in any other solid dosage form such as a tablet. Soft gelatin capsules are also highly suited to potent drugs, where the highly reproducible filling process helps ensure each Soft gelatin capsule has the same drug content, and because the operators are not exposed to any drug dust during the manufacturing process. Advantages are that they are easily swallowed due to tasteless shell. Volatile drug substances and hygroscopic drugs are better suited in soft gelatin capsules.

TABLETS
Tablet is a mixture of active substance and excipient, usually in powder form, pressed or compacted from a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavors to enhance taste; and pigments to make the tablets visually attractive. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf life), or to enhance the tablet's appearance. The compressed tablet is the most popular dosage form in use today. About two-thirds of all prescriptions are dispensed as solid dosage forms, and half of these are compressed tablets. A tablet can be formulated to deliver an accurate dosage to a specific site; it is usually taken orally, but can be administered sublingually, buccally, rectally or intravaginally. Medicinal tablets were originally made in the shape of a disk of whatever color their components determined, but are now made in many shapes and colors to help distinguish different medicines. Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified. Sizes of tablets to be swallowed range from a few millimeters to about a centimeter. Some tablets are in the shape of capsules, and are called "caplets". Medicinal tablets and capsules are often called pills. A pill is a small, round, solid pharmaceutical oral dosage form that was in use before the advent of tablets and capsules. Pills were made by mixing the active ingredients with an excipient such as glucose syrup in a mortar and pestle to form a paste, then rolling the mass into a long cylindrical shape and dividing it into equal portions, which were then rolled into balls, and often coated with sugar to make them more palatable.
Types of tablet
Immediate release tablets: The dosage form is designed to release the drug substance immediately after ingestion.
Delayed release: The drug substance is not released until a physical event has occurred, e.g., time elapsed, change in pit of intestinal fluids, change in gut flora.
Chewable tablets: These are strong, hard tablets to give good mouth feel. For example Lozenges Strong. These tablets are prepared for local delivery to mouth or throat often prepared by a candy moulding process.
Buccal tablets: These are designed to be placed in buccal cavity of mouth for rapid action.
Sublingual tablets: These are placed under the tongue for rapid dissolution.
Effervescent tablets: These are taken in water; the tablet forms an effervescent, often pleasant-tasting drink.
Advantages of tablets are Cheapest to manufactured and easy to pack, product identification is sample, and specialized profile products such as enteric coated or delayed release product are available. Tablets have best combined properties of chemicals, mechanical and microbiological stabilities.
INJECTIONS
Injections/injectables refer to drugs taken via injection. An injection is an infusion method of putting drug into the body, usually with a hollow needle and a syringe. These are sterile pyrogen free preparations intended to be administered parenterally.

An ampoule is a small sealed single dose vial which is used to contain medicine that must be protected from air and contaminants. They are sealed by melting the thin top with an open flame, and usually opened by snapping off the neck. The space above the chemical may be filled with an inert gas before sealing. The walls of glass ampoules are usually sufficiently strong to be brought into a glovebox without any difficulty. A multi-dose vial is a vial of liquid medication intended for parenteral administration that contains more than one dose of medication. Advantages are, rapid response is obtained and can be used when patient is uncooperative, or unconscious and when drug is unaffected by other route. 

Monday, 12 August 2013

A PROFESSIONAL WAY OF WRITING PRESCRIPTION

When a patient is received in hospital or clinic, immediately medication is started to save the patient. In performing the medicine administration, one should adhere to the six rights of medication administration

1. Right patient
2. Right medication
3. Right dose
4. Right route
5. Right time
6. Right documentation

Right Patient
Ensuring that the right patient receives the right drug is usually not a problem in prehospital care because typically only one patient is being treated. However, in some circumstances more than one patient may be undergoing treatment, especially in multiple casualty incidents in which many patients are involved. Care should be taken to distinguish the patients to avoid confusion and possible medication error.

Right Medication
 A common error in prehospital drug administration is selection of the wrong medication. Most emergency medications are supplied in ampules, vials, or prefilled syringes. Many look very similar. To ensure that the right drug is selected, one should carefully read the label. If the drug is supplied in a box, they should check the label on the box and compare it with the label on the vial or ampule itself after removing it from the box.
Drug preparations and concentrations can vary. In addition to checking the drug name, drug concentration should always be checked to ensure that the is the one desired. After the physician’s verbal order, pharmacist should repeat the order back to confirm that medication is correct and according to the physician order. The expiration date of a drug should always be checked prior to administration. The medication should be held up to the light and inspected for discoloration or particles in the solution. Expired and discolored medications should be discarded.

Right Dose
Administration of the correct drug dose is crucial. Errors in dosage occur in either calculating the correct dose or preparing the correct dose. Most drug orders are fairly straightforward, and many medications are supplied in unit-dose forms. In these cases, drug dosage calculation and drug preparation are easy. However, many medications, especially those administered by intravenous infusion, are much more difficult to dose. For these medications, paramedics should refer to standardized dosage charts to assist with preparation and administration of the desired dose.

Right Route
Most medications used in hospitals are designed to be given by the intravenous route. However, certain medications can be given by other routes depending on the physician’s orders. It is the pharmacist’s responsibility to know the various routes by which a particular drug can be administered. For example, the drugs hydroxyzine and promethazine are frequently used in the treatment of nausea. Promethazine can be administered both intravenously and intramuscularly. Hydroxyzine, in comparison, can be administered only by the intramuscular route.

Right Time
During the medication therapy, drugs may be administered repeatedly at specific time intervals. An important consideration is the rate and time during which a drug is administered. Many drugs can be administered rapidly as an intravenous bolus. Others must be administered at a specific rate.

Right Documentation
The drugs administered in the field can affect the medication therapy when patient get admitted in the hospital. So medication therapy must be completely documented that patient can get right medication while staying in the hospital.
All these six medication rights are only well managed when they are documented properly. The documentation from physician is called Prescription.

THE PRESCRIPTION
The word "prescription" stems from the Latin term praescriptus. Praescriptus is made up of two Latin word parts, prae-, a prefix meaning before, and scribere, a word root meaning to write. Putting it all together, prescription means "to write before," which reflects the historical fact that a prescription traditionally had to be written before a drug could be mixed and administered to a patient.
The prescription is one of the most important therapeutic transactions between physician, Pharmacist and patient. The art of prescription writing is an ancient inheritance. The ancients started their prescription with an appeal to the gods for its success. The ancient symbol, Rx, signifying the appeal, was established centuries ago and has been carried down to the present time.
Many ancient prescriptions were noted for their multiple ingredients and complexity of preparation. The importance of the prescription and the need for complete understanding and accuracy made it imperative that a universal and standard language be employed. Thus, Latin was adopted, and its use was continued until approximately a generation ago. Present-day prescription practices lead, for the most part, to prescriptions containing a single ingredient, written in English, with doses given in the metric system. The ancient "Rx" and the Latin "Signatura," abbreviated as "Sig.," are all that remain of the ancient art of the prescription.
Drug use is a complex process and there are many drug related challenges at various levels, involving prescriber, pharmacists and patients. While medication misadventure can occur anywhere in the health care system from prescriber to dispenser to administration and finally to patient use, To avoid undesirable and/or serious effects on the patient, both physician and pharmacist must render the highest of professional services. Accurate diagnosis; proper selection of medication, dosage form and route of administration; proper size and timing of dose; precise dispensing; accurate labeling; and correct packaging all must be provided.

Types of Drugs

Prescriptioned/Legend Drugs: These drugs may not be dispensed by a pharmacist without a prescription from a physician, veterinarian, dentist.

Controlled Drugs: In addition to requiring a prescription, these drugs require additional safeguards for storage. Refills are also limited. Both Government agencies promulgate regulations regarding these drugs.

Over-the-Counter (OTC) Drugs: These drugs do not require a prescription.

Pattern of Prescription

A prescription consists of;

o   Description of Prescriber
o   Description of Patient
o   Superscription
o   Inscription
o   Subscription
o   Signa
o   Signature of the Physician


Description of Prescriber
The name, qualification either MBBS, DVM, BDS, MD contact information including office number, emergency hours numbers and mobile number and address of the Prescriber are written in this section.

Description of Patient
Name of owner, address, description of the patient including age, color, sex, specie, breed, temperature, pulse, respiration, any physical abnormality should be mentioned in this section. The date when the prescription order is written with daily, monthly and yearly number should also be mentioned in this section.

Superscription

Rx is an important abbreviation written in this section. There are two school of thoughts about this abbreviation. One is about the Romans. They claimed that it is their symbol, they added in the prescription to add the blessings of their god of health called Jupiter just to add the blessing in the cure of disease. Second is about the Latins. They claimed that this word resemble to the symbol written in latin language which means "recipe," the Latin for "take thou." The English “you take”.

Inscription                                     
It is also called the body of the prescription. It consist of one or all of followings
  • A "basis" or chief ingredient indended to cure
  • An "adjuvant" to assist its action and make it cure quickly
  • A "corrective" to prevent or lessen any undesirable effect
  • A "vehicle" or "excipient" to make it suitable for administration and pleasant to the patient
Subscription
In this section directions are given to the pharmacist, usually consisting of a short sentence such as: "make a solution," "mix and place into 10 capsules," or "dispense 10 tablets" from the prescriber.

Signatura
From the Latin "signa," meaning "write," "make," or "label," this section. It contains the directions to the patient. These should always be written in English; however, physicians continue to insert Latin abbreviations, e.g. "1 cap t.i.d. pc," which the pharmacist translates into English, "take one capsule three times daily after meals." Since the pharmacist always writes the label in English. The directions to the patient should include a reminder of the intended purpose of the medication by including such phrases as "for pain," "for relief of headache," or "to relieve itching". Labeling; when the physician wants his patient to know the name of the drug, the box on the prescription form marked "label" should be checked. Refills; the physician should designate the number of refills he wishes the patient to have. Proprietary vs. Non-Proprietary ("Generic") Prescriptions.
In recent years, some hospitals and private physicians are indicating on the prescription their willingness or desire that the pharmacist dispense a non-proprietary or "generic-named" preparation instead of the trade name item written on the prescription. Some have a box on the prescription designated "N.P.P." In this way, the pharmacist can use a form of the drug which may be less expensive to the patient.
The amount to be dispensed should be clearly stated and should be that needed by the patient. Excessive amounts should never be dispensed, as it is not only expensive to the patient, but may lead to accumulation of medicines in the home, which later can cause harm to the patient or members of his family. It is far better to have several refills of a prescription than to have an excessive amount prescribed at one time.

LAWS AFFECTING PRESCRIPTION WRITING

Controlled Substances Act of 1970
Schedules of Controlled Drugs: The drugs that come under the jurisdiction of the Controlled Substances Act are divided into five schedules. Drugs can be scheduled, unscheduled, or moved from one schedule to another as the need arises. Schedules are as follows:
Schedule I
Drugs in this schedule have no accepted medical use in the United States and have a high abuse potential. Examples are heroin, marijuana, LSD, peyote, etc.
Schedule II
Drugs in this schedule have a high abuse potential with severe psychic or physical dependence liability. Included are certain narcotic analgesics, stimulants, and depressant drugs. Examples are opium, morphine, codeine, hydromorphone, methadone, meperidine, oxycodone, anileridine, cocaine, amphetamine, methamphetamine, phenmetrazine, methylphenidate, amobarbital, pentobarbital, secobarbital, methaqualone, and phencyclidine.
Schedule III
Drugs in this schedule have an abuse potential less than those in Schedules I and II and include compounds containing limited quantities of certain narcotic analgesic drugs, and other drugs such as barbiturates, glutethimide, methyprylon, and chlorphentemine. Any suppository dosage form containing amobarbital, secobarbital, or pentobarbital is in this schedule.
Schedule IV
Drugs in this schedule have an abuse potential less than those listed in Schedule III and include such drugs as barbital, phenobarbital, chloral hydrate, ethchlorvynol, meprobabmate, chlordizepoxide, diazepam, oxazepam, chloroazepate, flurazepam, etc.
Schedule V
Drugs in this schedule have an abuse potential less than those listed in Schedule IV and consist primarily of preparations containing limited quantities of certain narcotic analgesic drugs used for antitussive and antidiarrheal purposes.

USE OF TECHNOLOGY IN PRESCRIPTION WRITING
As prescription is nothing more than information among a prescriber, pharmacist and patient. Information technology can be applied to it. Existing information technology is adequate to print out prescriptions. Medical information systems in some hospitals do away with prescriptions within the hospital. There are proposals to securely transmit the prescription from the prescriber to the pharmacist using smartcard or the internet. In the United Kingdom a project called the Electronic Transfer of Prescriptions (ETP) within the National Program for IT is currently piloting such a scheme between prescribers and pharmacies.
Within computerized pharmacies, the information on paper prescriptions is recorded into a database. Afterwards, the paper prescription is archived for storage and legal reasons.
A pharmacy chain is often linked together through corporate headquarters with computer networking. Walgreens (largest American drug retailing chain) for example, uses satellite technology to share patient information. A person who has a prescription filled at one Walgreens can get a refill of that prescription at any other store in the chain, as well as have their information available for new prescriptions at any Walgreens.

Some online pharmacies also offer services to customers over the internet. They allow customers to order refills for medicine over the internet, and allows them to specify the store that they will pick up the medicine from. Many pharmacies now offer services to ship prescription refills right to the patient's home.